Application:
A common intermediate in asymmetric synthesis. Acetyltrimethylsilane is used in the production of novel histone deacetylase inhibitors for the treatment of Friedreich’s ataxia. It also aids in the preparation of conjugated polymers with an anthracene skeleton.A silyl protecting group used as a substrate for the synthesis of pyrazoles via the 1,3-bipolar cycloaddition of acetylene dinitrides and for nickel-catalyzed coupling reactions with benzyl cyanide.
Production Method:
First, using vinyl bromide and trimethylchlorosilane as starting materials, trimethylchloroethylen is synthesized via the Grignard reaction. This compound is then reacted with a brominating agent in the presence of a base to form 1-bromotrimethylchloroethylen. Finally, under the action of a strong base, one molecule of hydrogen bromide is removed to yield trimethylsilylacetylene.
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