Trimethyl(1-propynyl)silane CAS No:6224-91-5 C6H12Si 1-(Trimethylsilyl)-1-propyne

Introduction:

1-(Trimethylsilyl)propyne is a colorless liquid that can be used to synthesize highly substituted indenes via palladium-catalyzed carbocyclization; in the presence of Cp₂Zr(H)Cl, it can convert aldehydes into 1,3-dienes and other compounds.

Application:

1-(Trimethylsilyl)propyne is a silyl-alkyne derivative. Silyl-alkyne derivatives are important pharmaceutical intermediates, key silicon-based chemical raw materials, and important alkyne-functionalizing reagents; they serve as indispensable synthetic building blocks in the preparation of various monoalkynes and polyalkynes. It has numerous applications in heterocyclic chemistry, carbon–carbon coupling, drug synthesis, catalytic chemistry, and the materials industry.1-(Trimethylsilyl)propyne is an organic synthesis intermediate and a pharmaceutical intermediate. It is primarily used in laboratory research and development and in chemical and pharmaceutical synthesis processes, mainly for the synthesis of highly substituted indenes via a palladium-catalyzed carbocyclization reaction.Synthesis of highly substituted indenes via palladium-catalyzed carbocyclization. 1 was synthesized as dihydroindanone via a rhodium-catalyzed reaction with 2-bromophenylboronic acid.