Triisopropylsilane CAS No:6485-79-6, 6459-79-9 C9H22Si

Application:

Large-volume isopropyl groups (compared to ethyl groups) enable more selective reduction reactions (e.g., β-selective reduction of isocaprylyl C-phenyl ketones), but do not reduce their reactivity (e.g., Chemicalbook, trifluoromethanesulfonyl ketone-catalyzed reduction-etherification of trimethylsilyl ethers). Highly diastereoselective preparation of trans-1,2-diols catalyzed by Ni(O)N-heterocyclic carbene complexes.

Preparation:

First, magnesium metal is reacted with 2-chloropropane to synthesize isopropylmagnesium chloride; then, in the presence of a weakly polar solvent, triisopropylsilane is prepared at low temperatures using isopropylmagnesium chloride and trichlorosilane as starting materials. This invention employs a two-step synthesis method to produce triisopropylsilane. During the preparation of triisopropylsilane, a weakly polar solvent that does not affect the solubility of the reactants is used to alter the solvent’s polarity and prevent side reactions. This significantly reduces the formation of hard-to-separate impurities during the reaction, ultimately allowing high-purity triisopropylsilane to be obtained through simple distillation, with the product purity reaching 99%.