Main Applications:
1.Protecting Group Reagent: Primarily used to protect hydroxyl groups on alcohols, phenols, and amines; widely applied in the synthesis of nucleotides, sugars, natural products, and pharmaceutical molecules. Its SEM protecting group can be selectively removed under mild conditions.
2.Application Areas: Synthesis of pharmaceutical intermediates, pesticide R&D (to improve lipophilicity), and the preparation of functionalized siloxane polymers and surface modifiers.
3.Reaction Characteristics: Must be used in conjunction with a base (such as DIEA, NaH, etc.); sensitive to moisture and decomposes upon contact with water.
Storage and Safety Requirements:
1.Temperature Conditions: Recommended storage at -20°C in a freezer (some commercial grades specify 2–8°C, but -20°C is recommended for long-term stable storage); avoid prolonged storage at room temperature.
2.Environmental Requirements: Keep tightly sealed, dry, and protected from light; store in a cool place, away from oxidizing agents, acids, and sources of ignition.
3.Hazard Properties: Flammable liquid (flash point approximately 46.7°C), corrosive (GHS 02, GHS 05); UN Number 2920, Hazard Class 8 (Corrosive)/3 (Flammable Vapors).
4.Operating Procedures: Must be handled in a fume hood; wear corrosion-resistant gloves and safety goggles; use explosion-proof equipment.
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