Boronic Acid, B-[3-[5-[[ (2-fluorophenyl)Amino]Carbonyl]-2-Thienyl]Phenyl]- CAS 2285432-92-8

Key Applications

‌1. Cardiovascular Research: As a core pharmacological tool, it potently activates the three types of estrogen-related receptors—ERRα, ERRβ, and ERRγ—with an EC50 value of approximately 400 nM. By enhancing myocardial fatty acid metabolism and mitochondrial function, it plays a key role in mechanism studies related to heart failure protection and the maintenance of oxidative metabolism

2. Cellular Autophagy Research: Used to explore the molecular mechanisms by which estrogen-related receptors regulate cellular autophagy via the TFEB pathway; it is a popular positive control reagent in current research on cellular metabolism and autophagy pathways.

3. Drug Discovery: As a lead compound, it is used in early-stage screening and pharmacodynamic evaluation studies for innovative anti-heart failure and metabolic drugs targeting the ERR pathway.

Standard Storage Requirements

1. Environmental Protection Requirements: Strictly implement measures to protect against light and moisture. Avoid prolonged exposure of the product to light and high humidity to prevent a decline in biological activity due to oxidation or moisture absorption.

2. Shipping Guidelines: Research-grade products are typically shipped via blue ice cryogenic transport. Avoid high temperatures and prolonged exposure to light throughout the entire shipping process to ensure the product’s biological activity remains unaffected.